glp-1/gcgr dual agonist Design of a highly potent GLP-1R and GCGR dual-agonist for recovering hepatic fibrosis Schematic illustration of monoagonists, dual

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Drago, C

To date, these GLP-1 drugs have been approved to treat three adult populations: individuals with type 2 diabetes, individuals with a body mass index (BMI) of 30 or greater (obesity), and individuals with a BMI between 27 and 30 (overweight) with at least one weight-related health condition, such as cardiovascular disease, high blood pressure, high cholesterol, prior stroke, prior heart attack, and chest pain (angina)

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Furthermore, research on glioma cells (U251) shows that PEFs not only mediate apoptosis via the AP-1/Bim pathway but also involve other forms of regulated cell death (RCD), such as autophagy, necroptosis, and immunogenic cell death (ICD) (96)